Safety profile of chlorhexidine and povidone-iodine in rectal mucosa cleansing during prostate biopsy

Objective To evaluate the use of rectal mucosal cleansings before transrectal ultrasound-guided prostate biopsy with a approach, comparing safety profile chlorhexidine and povidone-iodine. Methods We conducted retrospective analysis our prospectively maintained database between August 2019 to September 2020 in high-volume hospital Cali, Colombia. 428 consecutive patients who underwent TRUS-PB approach were included this study. 117 received povidone-iodine 311 for mucosa cleansings. After procedure, we telephone follow-ups at 48 hours, 7 days, 30 days. The complications registered database. Analysis was performed using STATA 15. Results There statistically significant increased risk hematuria, urinary retention, bleeding those exposed Chlorhexidine (p <0.001, 0.01 respectively). did not find any differences sepsis ( p 0.18) or tract infection 0.77) rates groups. Rectal antisepsis significantly non-infectious complications. Conclusions In terms infectious complications, there no cleansing prior TRUS-PB. Povidone iodine appeared be safer option, as it is associated fewer risks bleeding, urine retention.